Research

Biomedical devices have enabled a revolution in medicine from research to diagnosis to treatment. In fact, the future of medicine is nothing but bright, with devices that will diagnose and treat diseases not only from outside but from inside the body, addressing localized malfunction in neurological, cardiovascular, autoimmune, cancer and other diseases. Such advanced technology requires miniaturization of implantable medical devices with a seamless integration of electronics and biology. In this vision, I am interested in using fundamental concepts from physics, biology and medicine to develop novel highly-integrated micro-systems that enable the next generation of medical technology.

The path towards the miniaturization of bioelectronics requires not only a reevaluation of existing paradigms but also an exploration of advanced IC processes and the hybrid integration of ICs with new materials, MEMS technology, and biological and chemical sensors and actuators. The transition to nanometer processes imposes new constrains for the design of analog circuits such as lower supply voltages and higher process variation, in applications that require low power solution in a small form-factor. Novel circuit techniques such as digitally-assisted analog circuits, self-healing circuits and 3D integration are just some new approaches that can be beneficial for implantable medical devices.


Projects

  • ATOMS: Addressable Transmitters Operated as Magnetic Spins

Localization of microscale devices in vivo using a novel microscale integrated circuit capable of mimicking the physical principles of nuclear magnetic resonance. ATOMS devices communicate via RF signals at magnetic-field dependent frequencies. Analogous
to the behavior of nuclear spins, these devices encode their location in space by shifting
their output frequency in proportion to the local magnetic field, and thus allow the use of external field gradients to precisely determine their location from their signal’s frequency. This technology is inherently robust to tissue properties, scalable to multiple devices, and suitable for the development of microscale devices to monitor and treat disease. In collaboration with Prof. Mikhail Shapiro.

  • Minimally-Invasive Biological Interfaces

Study of techniques, approaches and opportunities for integrated circuits in biological interfaces using biophysical methods such as magnetic resonance, ultrasound and infrared light.
Study of novel circuit and systems techniques for sensing and actuation of biological function using ATOMS

  • Wireless Implantable BioSensors

Design of high-sensitivity, high-dynamic range, and low-power micro-scale electrochemical sensors for measurement of different biomarkers such as glucose, proteins, enzymes and ions. In collaboration with Prof. Axel Scherer.

Most progressive vision loss occurs when the first layer of the retina (the photoreceptors) is damaged. Retinal prostheses aim to restore vision by bypassing the damaged photoreceptors and directly stimulating the remaining healthy neurons. Our approach uses highly scaled technologies to reduce area and power, and to support hundreds of channels for fully intraocular implants.

  • Circuit Techniques for Biomedical Implants

Development of novel circuit techniques for the design of biomedical devices in highly-scaled technologies.